South Tyrol is located in the north of Italy, south of Passo Brennero: The Autonomous Province adjoins Austria and Switzerland
From the North:
Coming from Munich you take the direction to Innsbruck (A12) via Rosenheim and Kufstein. At Innsbruck you follow the Brennerautobahn A13 until you reach the Brennero Pass, there the motorway passes into the Italian Brennero Motorway (A22). The first bigger village is Vipiteno.
From the West:
Via Ulm - Kempten - Füssen - Fernpass and Imst you reach Landeck. You take the Passo Resia state road and reach the Val Venosta valley in South Tyrol.
Coming from Bregenz you reach South Tyrol via Feldkirch - Arlberg - Landeck and the Passo Resia.
Coming from Switzerland you also can reach South Tyrol via Zürich - Landquart - Klosters - Vereinatunnel - Zernez and the Ofenpass.
From the East:
Via Klagenfurt - Lienz - Innichen you take the state road of Val Pusteria valley.
From the South:
If you come from Rome, Milano or Venice you have to follow the direction to Verona. There you take the Brennero Motorway A22 and reach South Tyrol via Trento.
To arrive to your holiday destination: