South Tyrol is located in the north of Italy, south of Passo Brennero: The Autonomous Province adjoins Austria and Switzerland.
Coming from Munich you take the direction to Innsbruck (A12 Inntalautobahn) via Rosenheim and Kufstein. At Innsbruck you follow the motorway A 13 (Brennerautobahn) until you reach the Brennerpass, there the motorway passes into the Italian Brennerautobahn (A22). The first bigger village in South Tyrol is Vipiteno (Sterzing).
Via Ulm - Kempten - Füssen - Fernpass and Imst you reach Landeck. You take the Passo Resia (Reschenpass)-state road and reach the Val Venosta (Vinschgau) in South Tyrol.
Coming from Bregenz you reach South Tyrol via Feldkirch - Arlberg - Landeck and the Passo Resia (Reschenpass).
Coming from Switzerland you also can reach South Tyrol via Zürich - Landquart - Klosters - Vereinatunnel - Zernez and the Ofenpass.
Via Klagenfurt - Lienz - Innichen you take the state road of Val Pusteria (Pustertal).
If you come from Rome, Milano or Venice you have to follow the direction to Verona. There you take the motorway A22 (Brennerautobahn) and reach South Tyrol via Trento.
To arrive to your holiday destination: